Service 01 — Cancer Genetics

Cancer Risk Gene Testing

BRCA · Lynch Syndrome · Hereditary Cancers

1 in 400
Indians estimated to carry a BRCA mutation
5–10%
of all breast & ovarian cancers are hereditary
70%
of hereditary cancers are preventable with early knowledge
#1
Breast cancer is now India's most common cancer in women

The Indian Context

Hereditary breast and ovarian cancer driven by BRCA1/BRCA2 mutations is significantly underdiagnosed in India. Certain communities — Punjabi, Bengali, Sindhi, and South Indian — carry founder mutations that are not captured in Western databases.

Lynch Syndrome, which predisposes to colorectal, endometrial, and ovarian cancers, is responsible for up to 3–5% of all colorectal cancers. Most families carrying Lynch mutations in India remain unaware.

Who Should Be Tested?

  • Breast cancer diagnosed under age 50
  • Two or more close relatives with breast or ovarian cancer
  • Ovarian cancer at any age in a blood relative
  • Male breast cancer in the family
  • Triple-negative breast cancer (any age)
  • Two or more primary cancers in same individual
  • Colorectal cancer with family clustering
  • Punjabi, Bengali, or South Indian ancestry

What We Screen For

Gene / Panel Cancer Risk Covered Recommended For
BRCA1 / BRCA2 Breast, Ovarian, Pancreatic, Prostate First-line for all women with family history
MLH1, MSH2, MSH6, PMS2 (Lynch Panel) Colorectal, Endometrial, Ovarian, Gastric Colorectal family clustering; early-onset CRC
PALB2, CHEK2, ATM Breast, Pancreatic (moderate–high risk) BRCA-negative with strong family history
Hereditary Cancer Panel (25+ genes) Comprehensive multi-cancer risk assessment Complex family history; multiple cancer types
Cascade Testing (known variant) Single variant confirmation in relatives Family members of a known positive carrier

After Your Test — What Happens Next

01
Pre-Test Counselling
Review of personal and family history. Selecting the right gene panel for your risk profile.
02
Blood Draw & Lab Processing
Simple 5 ml blood sample. Processed by NABL-accredited partner labs. Results in 14–21 days.
03
Results & Action Plan
Personal result session with your genomic counsellor. Surveillance plan, specialist referrals, and cascade testing for family.

Approximate Costs (INR)

Test Approx. Cost Notes
BRCA1 / BRCA2 (2-gene panel) ₹ 8,000 – 12,000 Most common first-line test
Lynch Syndrome Panel (4 genes) ₹ 12,000 – 18,000 For colorectal/endometrial family history
Hereditary Cancer Panel (25+ genes) ₹ 22,000 – 35,000 Broad multi-cancer coverage
Cascade Testing (family member) ₹ 3,500 – 6,000 Single known variant; discounted rate
Genetic Counselling (per session) ₹ 500 – 1,500 Pre- and post-test consultation